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Chemist Albert Hofmann, working at the Sandoz Corporation pharmaceutical laboratory in Switzerland, first synthesized LSD in 1938. He was conducting research on possible medical applications of various lysergic acid compounds derived from ergot, a fungus that develops on rye grass. Searching for compounds with therapeutic value, Hofmann created more than two dozen ergot-derived synthetic molecules.LSD is sold on the street in tablets, capsules, and occasionally in liquid form. It is an odorless and colorless substance with a slightly bitter taste that is usually ingested orally. It is often added to absorbent paper, such as blotter paper, and divided into small decorated squares, with each square representing one dose


Acid, blotter acid, window pane, dots, mellow yellow



The short-term effects of LSD are unpredictable. They depend on the amount of the drug taken; the user's personality, mood, and expectations; and the surroundings in which the drug is used. Usually, the user feels the first effects of the drug within 30 to 90 minutes of ingestion. These experiences last for extended periods of time and typically begin to clear after about 12 hours. The physical effects include dilated pupils, higher body temperature, increased heart rate and blood pressure, sweating, loss of appetite, sleeplessness, dry mouth, and tremors. Sensations may seem to "cross over" for the user, giving the feeling of hearing colors and seeing sounds. If taken in a large enough dose, the drug produces delusions and visual hallucinations.



LSD users often have flashbacks, during which certain aspects of their LSD experience recur even though they have stopped taking the drug. In addition, LSD users may develop long-lasting psychoses, such as schizophrenia or severe depression. LSD is not considered an addictive drug - that is, it does not produce compulsive drug-seeking behavior as cocaine, heroin, and methamphetamine do. However, LSD users may develop tolerance to the drug, meaning that they must consume progressively larger doses of the drug in order to continue to experience the hallucinogenic effects that they seek.
On March 31, 2003, William Leonard Pickard and Clyde Apperson were found guilty of one count of conspiracy to manufacture and distribute more than 10 grams of LSD from August 1999 to November 2000 and one count of possession with the intent to distribute more than 10 grams of LSD on November 6, 2000. The case involving these two individuals included the largest LSD lab seizure ever made by the DEA. Agents seized 41.3 kilograms of LSD and 23.6 kilograms of iso-LSD, a by-product from the manufacture of LSD. In the history of the DEA, there have only been 4 seizures of complete LSD labs. Three of these seizures involved Pickard and Apperson.




1. National Institute on Drug Abuse, Research Report: Hallucinogens and Dissociative Drugs, March 2001
2. National Institute on Drug Abuse, InfoFacts: LSD, February 2005
3. National Drug Intelligence Center (NDIC), LSD Fast Facts, May 2003
4. DEA Office of Diversion Control, d-Lysergic Acid Diethylamide
5. National Institute on Drug Abuse, Research Report: Hallucinogens and Dissociative Drugs, March 2001
6. NDIC, LSD Fast Facts, May 2003
7. NDIC, National Drug Threat Assessment 2006
8. DEA Office of Diversion Control, d-Lysergic Acid Diethylamide
9. National Institute on Drug Abuse and University of Michigan, Monitoring the Future 2005 Data From In-School Surveys of 8th-, 10th-, and 12th-Grade Students, December 2005
10. Drug Enforcement Administration, Press Release "Pickard and Apperson Convicted of LSD Charges: Largest LSD Lab Seizure in DEA History," March 31, 2003


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